synaptic membrane การใช้

• There are high concentrations of DHA in synaptic membranes of the brain.
• Cannabinoid receptors are G-protein coupled receptors located on the pre-synaptic membrane.
• Dendritic spikes allow backward propagating signals to reach and depolarize the post-synaptic membrane.
• AChR experiences multimerization within the post-synaptic membrane largely due to the signaling molecule Agrin.
• NMDA receptors are found throughout the post-synaptic membrane and act as a coincidence detector.
• BoNT / C also targets Syntaxin-1, another SNARE protein located in the synaptic membrane.
• The membrane association may be related to catecholamine packing in vesicles and export through the synaptic membrane.
• SynCAM is a cell adhesion molecule that is present in both pre-and post-synaptic membranes.
• AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh.
• As a result, amyloid beta promotes depolarization of the synaptic membrane, excessive calcium influx and mitochondrial impairment.
• CABP1 also interacts with CACNA1A in the pre and post synaptic membranes via C-terminal calcium binding motif.
• The NMDA detects both glutamate released by pre-synaptic vesicles and depolarization of the post-synaptic membrane.
• It is positioned several nanometers away from the pre-synaptic membrane and tethers 100 or more synaptic vesicles.
• PMKzeta continuously phosphorylates the GluR2 AMPA receptors to maintain their presence within the synaptic membrane ( Sacktor, 2011 ).
• It has been found to lead to Src, which itself phosphorylates GRIN2A, leading to its inclusion in the synaptic membrane.
• The long form of PNKD is neuronal specific and encodes a synaptic protein that localizes dominantly to the pre-synaptic membrane.
• They participate in long term potentiation and long term depression, and they are removed from the synaptic membrane in response to agonist binding.
• In general, post-synaptic depolarization occurs coincidentally with pre-synaptic activity when a backwards propagating signal reaches the post-synaptic membrane.
• Note that this affects gene transcription at a distance : the receptors that are embedded within the post-synaptic membrane are not susceptible to repression.
• Also, these signals recruit additional receptors into the post-synaptic membrane, stimulating the production of a modified receptor type, thereby facilitating an influx of calcium.